• C-X-C ligand 16 is an independent predictor of cardiovascular death and morbidity in acute coronary syndromes 

      Andersen, Thomas; Ueland, Thor; Ghukasyan Lakic, Tatevik; Åkerblom, Axel; Bertilsson, Maria; Aukrust, Pål; Michelsen, Annika E; James, Stefan K.; Becker, Richard C.; Storey, Robert F.; Wallentin, Lars; Siegbahn, Agneta; Kontny, Frederic (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-09-26)
      <i>Objective:</i> - The chemokine CXCL16 (C-X-C motif ligand 16) is a scavenger receptor for OxLDL (oxidized low-density lipoproteins) and involved in inflammation at sites of atherosclerosis. This study aimed to investigate the association of CXCL16 with clinical outcome in patients with acute coronary syndrome.<p> <p><i>Approach and Results:</i> - Serial measurements of CXCL16 were performed ...
    • Pentraxin-3 vs C-reactive Protein and Other Prognostic Biomarkers in Acute Coronary Syndrome: A Substudy of the Platelet Inhibition and Patients Outcomes (PLATO) Trial 

      Kontny, Frederic; Andersen, Thomas; Ueland, Thor; Åkerblom, Axel; Lakic, Tatevik G.; Michelsen, Annika; Aukrust, Pål; Bertilsson, Maria; Becker, Richard C.; Himmelmann, Anders; James, Stefan K.; Siegbahn, Agneta; Storey, Robert F.; Wallentin, Lars (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-04-24)
      <i>Aims</i>: We investigated the dynamics, associations with patient characteristics, other biomarkers, and clinical outcomes of pentraxin 3 in acute coronary syndrome.<p><p> <i>Methods and results</i>: In multivariate analyses, pentraxin 3 measured in 5154 patients randomised in the Platelet Inhibition and Patients Outcomes (PLATO) trial (NCT00391872) was compared with leukocytes, high-sensitivity ...
    • Procollagen type 1 N-terminal propeptide is associated with adverse outcome in acute chest pain of suspected coronary origin 

      Andersen, Thomas; Ueland, Thor; Aukrust, Pål; Nilsen, Dennis WT; Grundt, Magnea Heidi Jonsdottir; Staines, Harry; Pønitz, Volker; Kontny, Frederic (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-09-04)
      Background: Extracellular matrix (ECM) is an integral player in the pathophysiology of a variety of cardiac diseases. Cardiac ECM is composed mainly of collagen, of which type 1 is the most abundant with procollagen type 1 N-terminal Propeptide (P1NP) as a formation marker. P1NP is associated with mortality in the general population, however, its role in myocardial infarction (MI) is still uncertain, ...